The Analytical Biotechnology Laboratory started in April 2018 to elucidate the principle of biological system, which consists of complex interactive network of biological molecules (gene, protein, metabolite, cell, etc.). Understanding the mechanism of adaptation, robustness, and evolution through information technologies is beneficial to several fields including information, engineering, agriculture, and medicine. We try to achieve the quantitative elucidation of the property of biological system by analyzing various kinds of molecules using advanced analytical technologies. The extracted characteristics of the system by reconstructing the operating principle in silico and in vitro will contribute to the efficient and novel bioproduction and drug discovery.